Research News

This interesting short YouTube video explores the origins of Ozempic (semaglutide) and how it appears to protect cartilage in joints, perhaps even permitting cartilage re-grow. The mechanism is independent of weight loss. See https://www.youtube.com/watch?v=JM1he4pHzpw

Please note - one of the referenced studies in this video used hyaluronic acid (HA) injections for osteoarthritis. Some forms of HA are well know to promote fibrosis and in my opinion its use in arthrofibrosis is not wise.

Kayley

A Medical Xpress story summarises the risks associated with injectable peptides such as GHK-Cu, BPC-157 and TB-500, which are not approved for use in humans. See https://medicalxpress.com/news/2026-04-peptides-antiaging-trend-evidence-theyre.html?utm_source=nwletter&utm_medium=email&utm_campaign=daily-nwletter

Animal studies suggest that these peptides increase the production of several growth factors and cytokines that are key drivers of arthrofibrosis and cancer. BP-157 has been banned by all regulatory authorities. These peptides may also impact brain chemistry and there are reports of mood dysregulation, flu-like symptoms and joint pain.

In my opinion, it is not wise to try injectable peptides, especially if you have arthrofibrosis.

Kayley

The benefits of mindfulness meditation for physical and mental health are far reaching and well established. This Science X story discusses the role of acceptance in mindfulness https://medicalxpress.com/news/2026-03-benefits-mindfulness-meditation.html?utm_source=nwletter&utm_medium=email&utm_campaign=daily-nwletter

Acceptance of pain and disability does not mean giving up on improving your situation, but instead means noticing and accepting unpleasant experiences without fear or judgement.

Kayley

New research shows that the resolution of pain is an active process dependent on particular immune cells called monocytes. One particular type of monocyte produces a signaling molecule called IL10, which binds to nerve cells to turn off pain. More IL-10 is produced in men than in women.

Sim et al (2026 Neuroimmunology) say "In humans, pain resolved faster in men than in women after traumatic injury and was associated with higher circulating monocytes

and IL-10 levels in men". And "The slower resolution of pain in women increases their risk

of transitioning to chronic pain".

See https://medicalxpress.com/news/2026-02-chronic-pain-longer-women-immune.html?utm_source=nwletter&utm_medium=email&utm_campaign=daily-nwletter for the story.

Kayley