Now, semaglutide looks set to transform almost every area of medicine. These surprising benefits appear to be due to the potent anti-inflammatory and anti-fibrotic effects of semaglutide [1] on the whole body, with systemic reductions in oxidative stress and inflammatory cytokines [2] (the signalling molecules the body makes).

This blog summarises part of the information presented in Sebastiano Nutarelli’s IAA’s webinar “What is Arthrofibrosis and How to Diagnose It”. Sebastiano is an IAA Director, physiotherapist and clinical researcher at the European Knee Arthrofibrosis Centre. 

In Part 1 of this series, we explored how Dr. Marco Valoroso approaches the diagnosis of knee arthrofibrosis after total knee replacement (TKR), as well as the imaging tools and clinical reasoning that guide his evaluations. In this second half of our conversation, we turn to the surgical aspects of treatment — from manipulation under anesthesia to surgical strategies, revision decisions, and best practices to prevent recurrence.

Diagnosing and Causes of Arthrofibrosis After Total Knee Replacement: An Interview with Dr. Marco Valoroso. To shed light on this complex topic, I had the pleasure of speaking with Dr. Marco Valoroso, Head of Knee Surgery at the EOC hospitals in Lugano, Switzerland, and a leading specialist in the management of arthrofibrosis. In our conversation, Dr. Valoroso shares his insights into the causes and mechanisms behind knee arthrofibrosis and his multidisciplinary treatment ap