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Test for Infection

Don’t “Push through the pain”, be extremely careful with exercise

​Where inflammation is active needle aspiration of synovial fluid is necessary to conduct PCR testing for infection, with or without culture tests. Culture-based tests are not sufficiently sensitive to detect all types of infection.

In cases of prior injury or surgical procedure it is important to test the synovial fluid in the affected joint for infection. Synovial fluid is extracted by needle aspiration of the joint, often after flushing with sterile saline solution. Infections tests are particularly important for people with a prosthesis or metal “hardware” that microorganisms can adhere to.

Chronic low-grade infections often do not have the classic symptoms of redness, heat and swelling that are typical of acute infections, and may be missed by surgeons. This, together with the need for highly sensitive infection tests, means that chronic low-grade infections are notoriously difficult to diagnose. The traditional culture test is not adequately sensitive.

In addition to a culture test a molecular test called a PCR and sequencing should be performed on the synovial fluid. This test is more sensitive for identifying low numbers of bacteria that may be present in the joint. Next generation sequencing is a more advanced and powerful molecular test that is capable of identifying multiple microorganisms if these are present. 

Identification of microorganisms using molecular techniques permits the appropriate antibiotic (or other medication) to be prescribed.

It is also necessary to rule out infection prior to taking anti-inflammatory medications, since these increase the risk of infection.

Cytokine Panel

Traditional inflammatory markers such as CRP and ESR are typically not sensitive enough in arthrofibrosis. An inflammatory cytokine panel blood test is useful for guiding treatment.


Test for Infection

Where inflammation is active needle aspiration of synovial fluid is necessary to conduct PCR testing for infection, with or without culture tests.

Joint pain, Arthritis and tendon problems. a man touching nee at pain point.jpg


At present, the most effective imaging methods for arthrofibrosis include magnetic resonance imaging (MRI), ultrasound and PET/CT.

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The materials presented in this site are provided voluntarily as a public service. It is of a general nature, based on the scientific literature. The information and advice provided is made available in good faith but is provided solely on the basis that readers will be responsible for managing their own assessment of the matters discussed herein and that they should verify all relevant representations, statements and information. Please consult your doctor.

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