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This story in Medical Xpress explains recent research showing the link between chronic inflammation, pain and depression. See https://medicalxpress.com/news/2025-04-inflammation-link-chronic-pain-depression.html?utm_source=nwletter&utm_medium=email&utm_campaign=daily-nwletter
for the full story.
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Visit https://www.youtube.com/watch?v=GAha434oQyQ to view the discussion on the diagnosis, underlying causes, and treatment strategies for arthrofibrosis following total knee replacement (TKR or TKA).
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Medical Express News
by American College of Allergy, Asthma, and Immunology
edited by Stephanie Baum, reviewed by Robert Egan
Read the full story at https://medicalxpress.com/news/2025-11-people-allergies-eczema-higher-surgical.html?utm_source=nwletter&utm_medium=email&utm_campaign=daily-nwletter
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My good orthopedist (not to be confused with my surgeon) mentioned some researchon GLP1 and AF.
The studies I have found seem to focus on RA and osteoarthritis.
When the surgeon decided there was nothing else he could do for me the only suggestion he had was to see a different surgeon and do a complete revision and "make more room" for the adhesions. Though the other doctors I've seen say that based on the x rays, the positioning looks good.
I tried metformin for my last MUA with scope, but don't feel that it helped to stop new adhesions after the larger ones were removed.
Hi Erica,
Thanks for your post! I agree that semaglutide (Ozempic and Wegovy) shows interesting potential for helping arthrofibrosis, and my next blog is on this topic.
In my opinion, the science doesn't support the idea of "making more room" for adhesions and scar tissue, or doing a revision TKA without a clearly identified issue with the current prosthesis. Having a lysis of adhesions (LOA) helps some knees when the methods outlined in the "Surgery Checklist" on this website are followed. I hope this helps.
Kayley
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Post:
I am almost 5 years with arthrofibrosis from a knee replacement. I am at 3/80. The pain is unbearable. It has now moved up to my hip area along with the knee and my foot is asleep. I live alone. It is very hard Since some days. I can’t hardly walk. I am just wondering if there is anything new out there. I have been looked at by a surgeon at Cedars Sinai and he is deciding whether he wants to go ahead and put in a hinged knee with some radiation and clear out the scar tissue. This would be something that’s been done before. I’ve had two complete replacement replacements on this knee. The first knee Done and the surgeon didn’t move me for four days so that’s where I believe all of this begun. I have had many MUA’s and scar tissue removals done and I…
Hi Karen,
I can’t give medical advice because I’m not a clinician, but in my opinion revision knee replacements should not be performed unless there is a problem with the existing prosthesis – that is, if the prosthesis is loose, infected, or there is a mechanical problem that is clearly identified in the scans. I don’t believe that revisions should be performed only because of arthrofibrosis and in our experience repeating the surgery that appears to be the initiating "insult" often doesn’t lead to better outcomes.
I’m aware there are cost barriers, but I feel that it’s important to obtain the opinion of an experienced arthrofibrosis surgeon who is prepared to treat post-knee replacement patients with arthrofibrosis. If you’re able to see the surgeon Dr Jason Dragoo in Colorado, I think that would be helpful. Alternatively, you could request a telehealth appointment with the European Knee Arthrofibrosis Centre (EUKAF), email info@eukafcenter.ch. They can review your scans and provide clinical advice. They may suggest tests for nerve damage and infection, if these haven’t been performed already.
Please know that, unfortunately, you’re not alone and this is not a rare problem. It is, however, a real and complex problem that requires expertise and understanding.
I hope the website helps, please feel free to ask questions. There are also IAA interviews with experienced arthrofibrosis surgeons and physiotherapists available on YouTube, see https://www.youtube.com/@Arthrofibrosis.
All the best,
Kayley
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I am almost 5 years with arthrofibrosis from a knee replacement. I am at 3/80. The pain is unbearable. It has now moved up to my hip area along with the knee and my foot is asleep. I live alone. It is very hard Since some days. I can’t hardly walk.
I am just wondering if there is anything new out there. I have been looked at by a surgeon at Cedars Sinai and he is deciding whether he wants to go ahead and put in a hinged knee with some radiation and clear out the scar tissue. This would be something that’s been done before. I’ve had two complete replacement replacements on this knee.
The first knee replacement the surgeon didn’t move me for four days so that’s where I believe all of this begun. I have had many MUA’s and scar tissue removals done and I…
I am so sorry you are going through this.
The mental toll is unbearable at times.
Have you seen Dr Noyes in Ohio?
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In this group, explore research updates on Arthrofibrosis.
I'm curious if the IAA has ever created an arthrofibrosis patient survey? It would be interesting to compile data to research trends, etc.
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Welcome to our group Research News! A space for us to connect and share with each other. Start by posting your thoughts, sharing media, or creating a poll.
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Part 2 is now available for listening at https://open.spotify.com/episode/1Gl7No6mHRuBzdgQYH7m15?si=BCjNkbrhRMaL8THLe-zrZw
Kayley
I have psoriasis and eczema. This study is interesting.