International Arthrofibrosis Association
Our aims are to
Connect “best practice” evidence-based treatments and recent research with physicians, care providers and patients.
Create a movement and a community where we can support and learn from the experiences and insights of each of us.
Advocate for arthrofibrosis research and education.
Provide scientifically referenced and up to date information about arthrofibrosis to promote better outcomes.
Georgios Mavropalias interviews Dr. Kayley Usher about arthrofibrosis. Kayley has a research background in immunology and microbiology. Drawing on her scientific understanding of fibrosis, Kayley wrote a review paper called “Pathological mechanisms and therapeutic outlooks for arthrofibrosis”, published in Nature Bone Research in 2019. Since this time she has provided scientifically referenced information about the drivers of arthrofibrosis and treatment options.
“Arthrofibrosis literally means fibrosis of a joint and it can affect any joint."
“And it's essentially a wound healing response that doesn't stop when it should, so when healing is finished it should stop. But that wound healing response keeps going. It becomes pathological.”
“It's actually created by a special type of cell called myofibroblasts and these are normal cells that get transformed into this new kind of phenotype, and these create the internal scar tissue in the joint and they create adhesions and contractions.“
“Inflammation promotes fibrosis and then once it's going for too long, there’s always feedback effects that kick in between inflammation and fibrosis and it becomes self-perpetuating. So it becomes very, very difficult to resolve.”
“The impact of arthrofibrosis depends on which tissues are affected in the joint. Any of the tissues in the joint can be affected. So you can get fibrotic nerves, tendons, muscles, all of that.”
“They can be just sent away and told there's nothing wrong, or they might even be blamed for it, for non-compliance in physiotherapy, which is a common one.”
“I get a lot of people saying I feel gaslighted and traumatised by those kind of responses.”
“We also need society to be aware so that family understand, because quite often family don't understand and there's no obvious outward signs of what's wrong.”
Join the IAA
Become a Member
Become a member, share your story and join the arthrofibrosis movement. We can help each other and take a stand against arthrofibrosis by shining a light on this devastating and invisible condition.
Showcase your experience of living with arthrofibrosis by sharing your stories on social media. These can be funny, sad, or simply say how AF has impacted your life.
Our aim is to raise $15-20K to conduct a pilot study into the use of a new PET/CT tracer to accurately diagnose arthrofibrosis and directly assess the dynamics of the disease process.
By signing the petition
Help us stop more people from suffering disabling and painful arthrofibrosis by signing. With enough signatures we can lobby medical associations and governments in a number of countries.
Our mission is to provide scientifically referenced information about arthrofibrosis to promote better understanding and outcomes.
Become a member, share your story and join the arthrofibrosis movement. We can help each other by sharing information. By shining a light on arthrofibrosis and raising awareness about it in our community we will take a stand against the devastation it causes.
"Act as if what you do makes a difference. It does"
Contact International Arthrofibrosis Association
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