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Clinical trial

Taking into account that only 8% of phase 1 clinical trials are usually successful, when the clinical trial to test the antifibrotic drug PXS-5505 in arthrofibrosis arises, would the probability of it being successful also be only 8%?

3 answers0 replies

3 Comments

kayleyusher

Aug 18

Thanks for the question Alan. The answer is “no”, the percentage of successful outcomes from all clinical trials can’t be applied to the probability of any individual trial succeeding.

Unfortunately, we still haven’t found funding for this trial yet.

Kayley

Alan Campos

Aug 18

Replying to

ok, but if this clinical trial is carried out, would we also expect a low percentage of probability of success?

kayleyusher

Aug 20

Replying to

Hi Alan,

No, the probability of success depends on the variables associated with the individual case. You could use an analogy using a criminal case. Lets say that overall, there is only a 30% rate of successful prosecution of suspects. However, there is a weapon with your client's finger prints on it, several witnesses and security footage that clearly shows your client leaving with the stolen items. We would conclude that there is a greater than 30% chance of successful prosecution in this case.

Given what we know about the central role of LOX in scar tissue formation, and how scar tissue maintains myofibroblast activation, I believe there is a good chance that PXS-5505 would be effective and an important part of a treatment plan, especially early after surgery, but of course there are no guarantees.

Kayley